Synthesis and Biological Evaluation of N-Heterocyclic Substituted Fluoro-Benzothiazole Sulphonamido Analogs as a Potential Therapeutic Agents

Authors

  • Sri Ranga. T College of Pharmacy, Sri Satya Sai University of Technology and Medical sciences, Sehore (M.P)
  • Neelesh Chaubey College of Pharmacy, Sri Satya Sai University of Technology and Medical sciences, Sehore (M.P)

DOI:

https://doi.org/10.32553/jbpr.v11i1.893

Keywords:

Fluorobenzothiazole, Docking, antidiabetic

Abstract

The present investigation is aimed to synthesize fluorobenzothiazole comprising sulphonamido pyrazole analogs starting from fluoro-chloroaniline  to get 2-amino-6-fluoro-7-chloro (1,3) benzothiazole (I), this was treated with anilino-s-methyl ethylene cyanoacetamide  in the presence of ethanol to get desired molecules. The synthesized targeted molecules are characterized, docked and screened  for their invitro antidiabetic properties.

Keywords: Fluorobenzothiazole, Docking, antidiabetic

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Published

2022-01-11

How to Cite

T, S. R., & Chaubey, N. . (2022). Synthesis and Biological Evaluation of N-Heterocyclic Substituted Fluoro-Benzothiazole Sulphonamido Analogs as a Potential Therapeutic Agents. Journal of Biomedical and Pharmaceutical Research, 11(1). https://doi.org/10.32553/jbpr.v11i1.893

Issue

Vol. 11 No. 1 (2022)

Section

Articles

License

Creative Commons LicenseJournal of Biomedical and Pharmaceutical Research by Articles is licensed under a Creative Commons Attribution 4.0 International License.